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The Spirit Nuke is an attack used by Goku as a Super Saiyan 4 along with the Kaio-Ken X100. Not only does the Spirit Nuke take energy from every living thing in the universe like the Universal Spirit Bomb, it also takes energy from non-living things as well.
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The Spirit Nuke

It is one of the most powerful attacks ever. It sometimes is fired by a Kamehameha to increase accuracy, power, and speed. It was first used against Fission but even so it did no damage but this did kill Zerelb. If this attack is used by any of Goku's either of fusions, even Veku, it could destroy reality its self. The strongest this attack has ever been is when Super Saiyan 4 Vegito used it and gathered energy from HFIL, Other World, and Heaven as well and then fired from a Final Kamehameha x10.This is the strongest attack in all of time and space when used by Gogittenks.